Isenegger, Patrick G.. Asymmetric Morita-Baylis-Hillmann reaction : catalyst development and mechanistic insights based on mass spectrometric back reaction screening. 2016, PhD Thesis, University of Basel, Faculty of Science.
Restricted to Repository staff only until 1 June 2017.
Official URL: http://edoc.unibas.ch/diss/DissB_12002
In chapter 3, the synthesis of new morpholine- and piperidine-based triazolium salts and their use as NHC catalysts for the asymmetric cross-benzoin reaction is discussed. In particular, the cross-benzoin reaction between benzaldehyde and hydrocinnamaldehyde was studied. The aim of this project was to design a catalyst that could produce the desired cross-benzoin product with high enantiomeric excess and chemoselectivity.
Chapter 4 deals with the development of chiral NHC-phosphine ligands for the asymmetric iridium-catalyzed hydrogenation of different model substrates. This project was inspired by the previous work of Nanchen, a former member of the Pfaltz group. He synthesized a small library of different NHC-phosphine ligands for the hydrogenation of various substrates, however only moderate results in terms of reactivity and enantioselectivity were achieved. The aim of this project was to investigate NHC-based catalysts with conformationally more rigid structures.
|Advisors:||Pfaltz, Andreas and Baudoin, Olivier|
|Faculties and Departments:||05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource (371 Seiten)|
|Last Modified:||13 Feb 2017 10:42|
|Deposited On:||13 Feb 2017 10:42|
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