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Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex

Keck, Tara and Mrsic-Flogel, Thomas D. and Vaz Afonso, Miguel and Eysel, Ulf T. and Bonhoeffer, Tobias and Hübener, Mark. (2008) Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nature Neuroscience, 11 (10). pp. 1162-1167.

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Official URL: http://edoc.unibas.ch/49653/

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Abstract

The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical connections, but the dynamics of this reorganization process remain unknown. We used repeated intrinsic signal and two-photon imaging to monitor functional and structural alterations in adult mouse visual cortex over a period of months following a retinal lesion. The rate at which dendritic spines were lost and gained increased threefold after a small retinal lesion, leading to an almost complete replacement of spines in the deafferented cortex within 2 months. Because this massive remodeling of synaptic structures did not occur when all visual input was removed, it likely reflects the activity-dependent establishment of new cortical circuits that serve the recovery of visual responses.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Neural Networks (Mrsic-Flogel)
UniBasel Contributors:Mrsic-Flogel, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature America
ISSN:1097-6256
e-ISSN:1546-1726
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 11:10
Deposited On:28 Nov 2017 11:10

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