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Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection

Puri, Aaron W. and Broz, Petr and Shen, Aimee and Monack, Denise M. and Bogyo, Matthew. (2012) Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nature Chemical Biology, 8 (9). pp. 745-747.

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Official URL: http://edoc.unibas.ch/48479/

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Abstract

Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology
UniBasel Contributors:Broz, Petr
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1552-4450
e-ISSN:1552-4469
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Nov 2017 11:20
Deposited On:30 Nov 2017 11:20

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