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Wnt7A identifies embryonic gamma-motor neurons and reveals early postnatal dependence of gamma-motor neurons on a muscle spindle-derived signal

Ashrafi, Soha and Lalancette-Hébert, Melanie and Friese, Andreas and Sigrist, Markus and Arber, Silvia and Shneider, Neil A. and Kaltschmidt, Julia A.. (2012) Wnt7A identifies embryonic gamma-motor neurons and reveals early postnatal dependence of gamma-motor neurons on a muscle spindle-derived signal. The Journal of Neuroscience, 32 (25). pp. 8725-8731.

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Official URL: http://edoc.unibas.ch/47830/

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Abstract

Motor pools comprise a heterogeneous population of motor neurons that innervate distinct intramuscular targets. While the organization of motor neurons into motor pools has been well described, the time course and mechanism of motor pool diversification into functionally distinct classes remains unclear. ?-Motor neurons (?-MNs) and ?-motor neurons (?-MNs) differ in size, molecular identity, synaptic input and peripheral target. While ?-MNs innervate extrafusal skeletal muscle fibers to mediate muscle contraction, ?-MNs innervate intrafusal fibers of the muscle spindle, and regulate sensitivity of the muscle spindle in response to stretch. In this study, we find that the secreted signaling molecule Wnt7a is selectively expressed in ?-MNs in the mouse spinal cord by embryonic day 17.5 and continues to molecularly distinguish ?-from ?-MNs into the third postnatal week. Our data demonstrate that Wnt7a is the earliest known ?-MN marker, supporting a model of developmental divergence between ?- and ?-MNs at embryonic stages. Furthermore, using Wnt7a expression as an early marker of ?-MN identity, we demonstrate a previously unknown dependence of ?-MNs on a muscle spindle-derived, GDNF-independent signal during the first postnatal week.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia and Sigrist, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Society for Neuroscience
e-ISSN:1529-2401
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 15:21
Deposited On:04 Oct 2017 15:21

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