Rinner, Oliver and Seebacher, Jan and Walzthoeni, Thomas and Mueller, Lukas N. and Beck, Martin and Schmidt, Alexander and Mueller, Markus and Aebersold, Ruedi. (2008) Identification of cross-linked peptides from large sequence databases. Nature methods, 5 (4). pp. 315-318.
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Official URL: http://edoc.unibas.ch/45927/
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Abstract
We describe a method to identify cross-linked peptides from complex samples and large protein sequence databases by combining isotopically tagged cross-linkers, chromatographic enrichment, targeted proteomics and a new search engine called xQuest. This software reduces the search space by an upstream candidate-peptide search before the recombination step. We showed that xQuest can identify cross-linked peptides from a total Escherichia coli lysate with an unrestricted database search.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Proteomics (Schmidt) |
|---|---|
| UniBasel Contributors: | Schmidt, Alexander |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 1548-7091 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 14 Feb 2017 10:53 |
| Deposited On: | 14 Feb 2017 10:53 |
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