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Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina

Bahadori, R. and Biehlmaier, O. and Zeitz, C. and Labhart, T. and Makhankov, Y. V. and Forster, U. and Gesemann, M. and Berger, W. and Neuhauss, S. C. F.. (2006) Nyctalopin is essential for synaptic transmission in the cone dominated zebrafish retina. European Journal of Neuroscience, 24 (6). pp. 1664-1674.

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Official URL: http://edoc.unibas.ch/45813/

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Abstract

The first synapse in the vertebrate visual system is the photoreceptor synapse between rod and cone photoreceptors and the second-order bipolar cells. Although mutations in the nyctalopin gene (NYX) in humans lead to congenital stationary night blindness (CSNB1), affecting synaptic transmission between both types of photoreceptors and ON-bipolar cells, the function of nyctalopin in cone-dominant animal models has not been studied. Because the larval zebrafish retina is cone-dominant, we isolated the zebrafish nyx ortholog and raised a polyclonal antibody against the protein. Nyctalopin is expressed postsynaptically in both synaptic layers of the retina. Functional disruption via morpholino antisense injection leads to characteristic defects in the electroretinogram and defects in visual contrast sensitivity. We therefore demonstrated that nyctalopin plays a similar role in retinal synapse function in the cone pathway as in the rod pathway, thereby creating a genetic model for CSNB1 and its effects on cone vision.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Imaging Core Facility (Biehlmaier)
UniBasel Contributors:Biehlmaier, Oliver
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0953-816X
e-ISSN:1460-9568
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 12:22
Deposited On:27 Nov 2017 12:22

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