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Changes in IgE sensitization and total IgE levels over 20 years of follow-up

Amaral, André F. S. and Newson, Roger B. and Abramson, Michael J. and Antó, Josep M. and Bono, Roberto and Corsico, Angelo G. and de Marco, Roberto and Demoly, Pascal and Forsberg, Bertil and Gislason, Thorarinn and Heinrich, Joachim and Huerta, Ismael and Janson, Christer and Jõgi, Rain and Kim, Jeong-Lim and Maldonado, José and Martinez-Moratalla Rovira, Jesús and Neukirch, Catherine and Nowak, Dennis and Pin, Isabelle and Probst-Hensch, Nicole and Raherison-Semjen, Chantal and Svanes, Cecilie and Urrutia Landa, Isabel and van Ree, Ronald and Versteeg, Serge A. and Weyler, Joost and Zock, Jan-Paul and Burney, Peter G. J. and Jarvis, Deborah L.. (2015) Changes in IgE sensitization and total IgE levels over 20 years of follow-up. Journal of allergy and clinical immunology, 137 (6). 1788-1795.e9.

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Official URL: http://edoc.unibas.ch/45238/

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Abstract

Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.; We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.; Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.; Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.; Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Publisher:Mosby
ISSN:0091-6749
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:08 Dec 2016 10:10
Deposited On:08 Dec 2016 10:10

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