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CRISPR and the Rebirth of Synthetic Biology

Heidari, Raheleh and Shaw, David Martin and Elger, Bernice Simone. (2016) CRISPR and the Rebirth of Synthetic Biology. Science and Engineering Ethics, 23 (2). pp. 351-363.

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Official URL: http://edoc.unibas.ch/45076/

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Abstract

Emergence of novel genome engineering technologies such as clustered regularly interspaced short palindromic repeat (CRISPR) has refocused attention on unresolved ethical complications of synthetic biology. Biosecurity concerns, deontological issues and human right aspects of genome editing have been the subject of in-depth debate; however, a lack of transparent regulatory guidelines, outdated governance codes, inefficient time-consuming clinical trial pathways and frequent misunderstanding of the scientific potential of cutting-edge technologies have created substantial obstacles to translational research in this area. While a precautionary principle should be applied at all stages of genome engineering research, the stigma of germline editing, synthesis of new life forms and unrealistic presentation of current technologies should not arrest the transition of new therapeutic, diagnostic or preventive tools from research to clinic. We provide a brief review on the present regulation of CRISPR and discuss the translational aspect of genome engineering research and patient autonomy with respect to the "right to try" potential novel non-germline gene therapies.
Faculties and Departments:08 Cross-disciplinary Subjects > Ethik > Institut für Bio- und Medizinethik > Bio- und Medizinethik (Elger)
03 Faculty of Medicine > Departement Public Health > Ethik in der Medizin > Bio- und Medizinethik (Elger)
UniBasel Contributors:Elger, Bernice Simone and Heidari, Raheleh and Shaw, David
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Verlag
ISSN:1353-3452
e-ISSN:1471-5546
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 06:38
Deposited On:04 Oct 2017 06:38

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