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Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire

Coulibaly, Jean T. and Ouattara, Mamadou and Keiser, Jennifer and Bonfoh, Bassirou and N'Goran, Eliézer K. and Andrews, Jason R. and Bogoch, Isaac I.. (2016) Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire. American journal of tropical medicine and hygiene, 95 (4). pp. 831-834.

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Official URL: http://edoc.unibas.ch/44553/

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Abstract

Portable microscopy may facilitate quality diagnostic care in resource-constrained settings. We compared a handheld light microscope (Newton Nm1) with a mobile phone attachment to conventional light microscopy for the detection of Plasmodium falciparum in a cross-sectional study in rural Côte d'Ivoire. Single Giemsa-stained thick blood film from 223 individuals were prepared and read by local laboratory technicians on both microscopes under 1,000× magnification with oil. Of the 223 samples, 162 (72.6%) were P. falciparum positive, and the overall mean parasite count was 1,392/μL of blood. Sensitivity and specificity of the handheld microscope was 80.2% (95% confidence interval [CI]: 73.1-85.9%) and 100.0% (95% CI: 92.6-100.0%), respectively, with a positive and negative predictive value of 100.0% (95% CI: 96.4-100.0%) and 65.6% (95% CI: 54.9-74.9%), respectively. If sensitivity can be improved, handheld light microscopy may become a valuable public health tool for P. falciparum diagnosis.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Keiser, Jennifer and Bonfoh, Bassirou
Item Type:Article, refereed
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Dec 2016 14:08
Deposited On:12 Dec 2016 14:08

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