Eze, Ikenna Collins. The role of air pollution in the aetiology of type 2 diabetes. 2015, PhD Thesis, University of Basel, Faculty of Science.
Available under License CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives).
Official URL: http://edoc.unibas.ch/diss/DissB_11830
Methods. First, this work summarized the existing evidence on the possible relationship between long-term exposure to air pollutants and type 2 diabetes. Furthermore, in the framework of the first follow-up of SAPALDIA- the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, this work used indices for long-term exposure air pollution – 10-year mean particulate matter <10μm in diameter [PM10] and nitrogen dioxide [NO2] - assigned to participants’ residences using a combination of Gaussian dispersion and Land-use regression models, participants residential histories and pollutant trends at monitoring stations. It identified diabetes and metabolic syndrome cases in a comprehensive way considering self-reports, blood tests and other physical measures. It additionally identified genetic variants through genotyping on two different arrays – the Human Illumina610quad Bead Chip and the Taqman PCR assay - for 63 type 2 diabetes genetic polymorphisms [towards a diabetes gene score] and a functional polymorphism on the IL6 gene respectively. Based on the above and detailed health socio-demographic and lifestyle characteristics including smoking habits, occupational exposures, alcohol, nutrition, physical activity, body measurements and additional data collected in SAPALDIA, it was ideal to investigate the cross-sectional relationships between air pollutants and diabetes and to explore interactions [based on various susceptibilities] to understand mechanisms involved in the relationship between long-term exposure to air pollutants and type 2 diabetes.
Results. In this work, we found a positive relationship between PM2.5 and NO2 and the risk of T2D in the pooled evidence synthesized from electronic databases. In the frame of SAPALDIA biobank, we found a moderate positive association between long-term exposure to PM10 [and NO2] and prevalent diabetes, and demonstrated a sustained effect of PM10 independent of NO2, while NO2 lost its association on accounting for PM10 in multi-pollutant models. Among the measures of cardio-metabolic function, PM10 impacted most on impairment of glucose homeostasis and least on blood lipoproteins and triglycerides. The relationship between PM10 and impaired fasting glycaemia was more apparent among the physically active. Age also appeared to influence the relationship between PM10 and impaired fasting glycaemia. People at higher polygenic risk for type 2 diabetes were more susceptible to PM10. Genetic risk for insulin resistance and obesity appeared to be more relevant than those for beta-cell function in modifying the effects of PM10, especially among those with some background inflammatory conditions. Carriers of the pro-inflammatory major ‘G’ allele of IL6-572GC, with allele frequency of 93%, were also more susceptible to PM10 in relation to diabetes.
Conclusions. This work has greatly contributed to evidence suggesting the possible role of air pollutants in diabetes aetiology. The reported associations were observed at mean concentrations below current air quality guidelines. PM10 may be a good marker for aspects of air pollution [rather than NO2] relevant for the development of diabetes. In particular, PM10 might act through sub-clinical inflammation and resultant impaired insulin sensitivity. Impairment of insulin secretion may be a less relevant pathway for PM10 action. Physical activity, though beneficial, presented another likely pathway for PM10 effects. These findings, if confirmed, call for the strengthening of air quality policies and adaptation of physical activity promotion to environmental contrasts. Future studies should explore the totality of environmental exposures – exposomics –in a life-course fashion. The mediating role of DNA methylation influencing genetic expression should be further explored. For global generalizability, there is a strong need for evidence replication in developing countries where outdoor and indoor air pollution is quite high and mostly unregulated, and the burden of non-communicable diseases is rapidly growing.
|Advisors:||Probst-Hensch, Nicole and Kronenberg, Florian|
|Faculties and Departments:||09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource (xvi, 226 Seiten)|
|Last Modified:||10 Oct 2016 06:01|
|Deposited On:||10 Oct 2016 06:01|
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