Masudi, Tafheem. Connectivity motifs underlying neuronal computations in the adult OB. 2016, PhD Thesis, University of Basel, Faculty of Science.
Restricted to Repository staff only until 31 December 2017.
Official URL: http://edoc.unibas.ch/diss/DissB_11784
Two recent computational studies focused on reciprocal connectivity in the OB between mitral cells and granule cells. One model predicts that granule cells activity is ultra-sparse and mitral cell activity is sparse, and that this type of reciprocal circuit helps to perform decorrelation in the OB. Another computational model used the same mathematical approach but comes with different predictions. It puts no constrains on the sparseness of MC and GC cells. It further predicts that the reciprocal circuit performs contrast normalization and brings the OB into a variance-balanced state. We tested both these models experimentally and saw indeed that the granule cell activity was not sparse, thereby showing that the first model is not biologically plausible in the OB. The fraction of reciprocal synapses out of all the input synapses on the mitral cells was significant. With this fraction the olfactory circuit still performs strong contrast normalization thereby showing that the second model is biologically plausible.
|Advisors:||Friedrich, Rainer W. and Scheiffele, Peter|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Scheiffele)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource (93 Seiten)|
|Last Modified:||03 Oct 2016 13:58|
|Deposited On:||03 Oct 2016 13:58|
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