edoc

Limited genetic diversity of Hepatitis b virus in the general population of the offin river valley in Ghana

Ampah, Kobina Assan and Pinho-Nascimento, Carlos Augusto and Kerber, Sarah and Asare, Prince and De-Graft, Daniel and Adu-Nti, Frank and Paixão, Izabel C. N. P. and Niel, Christian and Yeboah-Manu, Dorothy and Pluschke, Gerd and Röltgen, Katharina. (2016) Limited genetic diversity of Hepatitis b virus in the general population of the offin river valley in Ghana. PLoS one, 11 (6). e0156864.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/43671/

Downloads: Statistics Overview

Abstract

Hepatitis B virus (HBV) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. Co-infection with HBV and hepatitis delta virus (HDV) may lead to the most severe form of viral hepatitis. In Ghana, knowledge on the prevalence of HBV and HDV in the general population is scanty and the few genetic analyses of the prevailing HBV genotypes are dating back more than a decade. In the present study, 1,323 serum samples from individuals living in a rural area (Offin river valley) of Ghana were analyzed for the presence of the hepatitis B surface antigen (HBsAg). Positive sera were subsequently tested for the presence of anti-HDV antibodies. A total of 107 (8%) sera were HBsAg positive with an 8.4% prevalence of anti-HDV antibodies among the HBsAg positives. Phylogenetic analysis based on HBV pre-S/S sequences, attributed all 52 typable samples to genotype E. All belonged to serotype ayw4. While 19 sequences clustered with those from a number of African countries, the other 33 formed a separate cluster distinguished by an intergroup mean distance of 1.5% from the pan-African HBV/E cluster. Successful implementation of HBV vaccination in the region was reflected by the low HBsAg carrier rate of 1.8% among children ≤11 years.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Article, refereed
Publisher:Public Library of Science
ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2016 13:54
Deposited On:31 Aug 2016 13:54

Repository Staff Only: item control page