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Omega-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk

Brick, Tabea and Schober, Yvonne and Böcking, Christian and Pekkanen, Juha and Genuneit, Jon and Loss, Georg and Dalphin, Jean-Charles and Riedler, Josef and Lauener, Roger and Nockher, Wolfgang Andreas and Renz, Harald and Vaarala, Outi and Braun-Fahrländer, Charlotte and von Mutius, Erika and Ege, Markus Johannes and Pfefferle, Petra Ina and Pasture study group, . (2016) Omega-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk. Journal of allergy and clinical immunology, 137 (6). 1699-1706.e13.

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Official URL: http://edoc.unibas.ch/43665/

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Abstract

Living on a farm has repeatedly been shown to protect children from asthma and allergies. A major factor involved in this effect is consumption of unprocessed cow's milk obtained directly from a farm. However, this phenomenon has never been shown in a longitudinal design, and the responsible milk components are still unknown.; We sought to assess the asthma-protective effect of unprocessed cow's milk consumption in a birth cohort and to determine whether the differences in the fatty acid (FA) composition of unprocessed farm milk and industrially processed milk contributed to this effect.; The Protection Against Allergy-Study in Rural Environments (PASTURE) study followed 1133 children living in rural areas in 5 European countries from birth to age 6 years. In 934 children milk consumption was assessed by using yearly questionnaires, and samples of the "usually" consumed milk and serum samples of the children were collected at age 4 years. Doctor-diagnosed asthma was parent reported at age 6 years. In a nested case-control study of 35 asthmatic and 49 nonasthmatic children, 42 FAs were quantified in milk samples.; The risk of asthma at 6 years of age was reduced by previous consumption of unprocessed farm milk compared with shop milk (adjusted odds ratio for consumption at 4 years, 0.26; 95% CI, 0.10-0.67). Part of the effect was explained by the higher fat content of farm milk, particularly the higher levels of ω-3 polyunsaturated FAs (adjusted odds ratio, 0.29; 95% CI, 0.11-0.81).; Continuous farm milk consumption in childhood protects against asthma at school age partially by means of higher intake of ω-3 polyunsaturated FAs, which are precursors of anti-inflammatory mediators.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Microbial Exposure & Childhood Allergies (Braun-Fahrländer)
UniBasel Contributors:Loss, Georg and Braun-Fahrländer, Charlotte
Item Type:Article, refereed
Publisher:Mosby
ISSN:0091-6749
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Jan 2017 09:05
Deposited On:31 Aug 2016 13:44

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