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Occupational exposure and risk of chronic obstructive pulmonary disease : a systematic review and meta-analysis

Alif, Sheikh M. and Dharmage, Shyamali C. and Bowatte, Gayan and Karahalios, Amalia and Benke, Geza and Dennekamp, Martine and Mehta, Amar J. and Miedinger, David and Künzli, Nino and Probst-Hensch, Nicole and Matheson, Melanie C.. (2016) Occupational exposure and risk of chronic obstructive pulmonary disease : a systematic review and meta-analysis. Expert review of respiratory medicine, 10 (8). pp. 861-872.

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Official URL: http://edoc.unibas.ch/43618/

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Abstract

Due to contradictory literature we have performed a systematic review and meta-analyse of population-based studies that have used Job Exposure Matrices to assess occupational exposure and risk of Chronic Obstructive Pulmonary Disease (COPD).; Two researchers independently searched databases for published articles using predefined inclusion criteria. Study quality was assessed, and results pooled for COPD and chronic bronchitis for exposure to biological dust, mineral dust, and gases/fumes using a fixed and random effect model. Five studies met predetermined inclusion criteria. The meta-analysis showed low exposure to mineral dust, and high exposure to gases/fumes were associated with an increased risk of COPD. We also found significantly increased the risk of chronic bronchitis for low and high exposure to biological dust and mineral dust. Expert commentary: The relationship between occupational exposure assessed by the JEM and the risk of COPD and chronic bronchitis shows significant association with occupational exposure. However, the heterogeneity of the meta-analyses suggests more wide population-based studies with older age groups and longitudinal phenotype assessment of COPD to clarify the role of occupational exposure to COPD risk.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
UniBasel Contributors:Künzli, Nino and Probst Hensch, Nicole
Item Type:Article, refereed
Publisher:Taylor & Francis Group
ISSN:1747-6356
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2016 13:02
Deposited On:31 Aug 2016 13:02

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