Jones, Amy J. and Kaiser, Marcel and Avery, Vicky M.. (2015) Identification and characterization of FTY720 for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 60 (3). pp. 1859-1861.
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Official URL: http://edoc.unibas.ch/42162/
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Abstract
The screening of a focused library identified FTY720 (Fingolimod; Gilenya) as a potent selective antitrypanosomal compound active against Trypanosoma brucei gambiense and T. brucei rhodesiense, the causative agents of human African trypanosomiasis (HAT). This is the first report of trypanocidal activity for FTY720, an oral drug registered for the treatment of relapsing multiple sclerosis, and the characterization of sphingolipids as a potential new class of compounds for HAT.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 1098-6596 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 12 Dec 2016 12:24 |
| Deposited On: | 28 Apr 2016 09:24 |
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