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Estimation of the antirelapse efficacy of tafenoquine, using Plasmodium vivax genotyping

Beck, Hans-Peter and Wampfler, Rahel and Carter, Nick and Koh, Gavin and Osorio, Lyda and Rueangweerayut, Ronnatrai and Krudsood, Srivcha and Lacerda, Marcus V. and Llanos-Cuentas, Alejandro and Duparc, Stephan and Rubio, Justin P. and Green, Justin A.. (2016) Estimation of the antirelapse efficacy of tafenoquine, using Plasmodium vivax genotyping. Journal of infectious diseases, 213 (5). pp. 794-799.

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Official URL: http://edoc.unibas.ch/42130/

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Abstract

Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled phase 2b study in Peru, India, Thailand, and Brazil allowed determination of genetically heterologous or homologous P. vivax infection recurrence following receipt of chloroquine plus one of 4 doses of tafenoquine (50, 100, 300, or 600 mg) or chloroquine plus primaquine, compared with receipt of chloroquine alone. The antihypnozoite efficacy of tafenoquine was evident as a reduction in homologous recurrences of P. vivax infection as drug doses were increased. No clear dose-response pattern was evident for heterologous recurrences of P. vivax infection. Rates of homologous recurrence of P. vivax infection appear to be clinically useful for comparing drug efficacy for the prevention of P. vivax infection relapse.; NCT01376167.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Parasitology and Epidemiology (Beck)
UniBasel Contributors:Beck, Hans-Peter
Item Type:Article, refereed
Publisher:Oxford University Press
ISSN:0022-1899
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:03
Deposited On:28 Apr 2016 07:41

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