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Diagnosis of Opisthorchis viverrini infection with handheld microscopy in Lao People's Democratic Republic

Bogoch, Isaac I. and Sayasone, Somphou and Vonghachack, Youthanavanh and Meister, Isabel and Utzinger, Jürg and Odermatt, Peter and Andrews, Jason R. and Keiser, Jennifer. (2016) Diagnosis of Opisthorchis viverrini infection with handheld microscopy in Lao People's Democratic Republic. American journal of tropical medicine and hygiene, 94 (1). pp. 158-160.

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Official URL: http://edoc.unibas.ch/41963/

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Abstract

Opisthorchiasis is a neglected tropical disease, yet it is of considerable public health importance in Southeast Asia given the predilection for chronically infected persons to develop cholangiocarcinoma. We evaluated a handheld microscope for the diagnosis of Opisthorchis viverrini in a community-based setting in Lao People's Democratic Republic in comparison with conventional light microscopy. In stool samples collected from 104 individuals, handheld microscopy revealed a sensitivity of 70.6% and a specificity of 89.5% for O. viverrini infection. Pearson's correlation for quantitative fecal egg counts between the two devices was 0.98 (95% confidence interval: 0.98-0.99). With small adjustments to further increase diagnostic sensitivity, a handheld microscope may become a helpful tool to screen for O. viverrini and other helminth infections in public health settings.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Utzinger, Jürg and Keiser, Jennifer
Item Type:Article, refereed
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:03
Deposited On:19 Apr 2016 09:49

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