Harrisberger, Fabienne. Brain structural alterations, genetic risk variants and the onset of psychosis. 2015, PhD Thesis, University of Basel, Faculty of Medicine.
Available under License CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives).
Official URL: http://edoc.unibas.ch/diss/DissB_11614
In this thesis, I will present research for a deeper characterisation of the hippocampus in schizophrenia, first-episode of psychosis and the at-risk mental state and the association to genetic risk variants. First, we we found no association of the brain- derived neurotrophic factor rs6265 polymorphism with the hippocampal volumes neither in the original analysis of large cohort of young healthy individuals nor a meta-analysis with 5298 healthy subjects in total. Moreover, we detected differences between the applied hippocampal measuring techniques, i.e. manual or automated segmentation. Second, a meta-analysis of the same association but in 18 independent neuropsychiatric patient cohorts including schizophrenia revealed again no association. Also, we showed similar hippocampal reductions for Val/Val homozygote and Met-carrier patients compared to healthy controls. Third, group- related comparison of subcortical volumes revealed hippocampal and thalamic reductions in at-risk mental state individuals compared to healthy controls. Moreover, we found comparable medium effect sizes for both structures assessed with two different statistical methods. Fourth, in a cohort of at-risk mental state individuals and first-episode of psychosis patients we found a negative association between the hippocampal volumes and a polygenic schizophrenia-related risk score. Furthermore, a higher polygenic schizophrenia-related risk score was significantly associated with a higher probability of an individual being assigned to the first-episode of psychosis group compared to the total at-risk mental state group.
These studies aid a better understanding of hippocampal volume reduction and genetic variants associated with schizophrenia, first-episode of psychosis and the at- risk mental state.
|Advisors:||Borgwardt, Stefan and Papassotiropoulos, Andreas and Nichols, Thomas|
|Faculties and Departments:||03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Neuropsychiatrie (Borgwardt)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource (126 Seiten)|
|Last Modified:||30 Jun 2016 11:01|
|Deposited On:||01 Apr 2016 11:45|
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