Vogel, Elisabeth. GABAergic plasticity in neuronal circuits of fear. 2015, PhD Thesis, University of Basel, Faculty of Science.
Restricted to Repository staff only until 1 January 2018.
Available under License CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives).
Official URL: http://edoc.unibas.ch/diss/DissB_11669
In my thesis I focused on how GABAergic transmission onto pyramidal cells is organized in fear circuits. First, in a broad approach and in collaboration with Yu Kasugai and Franceso Ferraguti from the Medical University Innsbruck, we show that fear conditioning induces functional and ultrastructural changes at inhibitory synapses. Following fear learning, GABAergic transmission is enhanced, which is correlated with an enlargement of synapses and a change in receptor subunit composition.
Second, in target specific experiments, I studied the dynamic regulation of inhibition from CCK expressing interneurons onto two functionally distinct classes of projections neurons. Data indicate that characteristics at these synapses facilitate asymmetric activity of particular pyramidal cell populations via retrograde endocannabinoid signaling and that inhibitory control is organized in a cell type specific manner.
|Advisors:||Lüthi, Andreas and Bischofberger, Josef|
|Faculties and Departments:||09 Associated Institutions > Friedrich Miescher Institut FMI > Cellular mechanisms of learning and memory (Lüthi)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource (95 Seiten)|
|Last Modified:||01 Sep 2016 08:06|
|Deposited On:||01 Sep 2016 08:05|
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