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Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase

Zhao, Jingming and Kajetanowicz, Anna and Ward, Thomas R.. (2015) Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase. Organic and Biomolecular Chemistry, 13 (20). pp. 5652-5655.

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Abstract

An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Zhao, Jingming and Kajetanowicz, Anna and Ward, Thomas R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1477-0520
e-ISSN:1477-0539
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
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Last Modified:02 Jul 2019 08:00
Deposited On:03 May 2016 13:46

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