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Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex

Poort, Jasper and Khan, Adil G. and Pachitariu, Marius and Nemri, Abdellatif and Orsolic, Ivana and Krupic, Julija and Bauza, Marius and Sahani, Maneesh and Keller, Georg B. and Mrsic-Flogel, Thomas D. and Hofer, Sonja B.. (2015) Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron, 86 (6). pp. 1478-1490.

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Official URL: http://edoc.unibas.ch/40014/

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Abstract

We determined how learning modifies neural representations in primary visual cortex (V1) during acquisition of a visually guided behavioral task. We imaged the activity of the same layer 2/3 neuronal populations as mice learned to discriminate two visual patterns while running through a virtual corridor, where one pattern was rewarded. Improvements in behavioral performance were closely associated with increasingly distinguishable population-level representations of task-relevant stimuli, as a result of stabilization of existing and recruitment of new neurons selective for these stimuli. These effects correlated with the appearance of multiple task-dependent signals during learning: those that increased neuronal selectivity across the population when expert animals engaged in the task, and those reflecting anticipation or behavioral choices specifically in neuronal subsets preferring the rewarded stimulus. Therefore, learning engages diverse mechanisms that modify sensory and non-sensory representations in V1 to adjust its processing to task requirements and the behavioral relevance of visual stimuli.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Neuronal circuits and brain function (Hofer)
UniBasel Contributors:Hofer, Sonja and Mrsic-Flogel, Thomas and Khan, Adil Ghani and Nemri, Abdellatif and Orsolic, Ivana
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:0896-6273
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:00
Deposited On:01 Jun 2016 06:51

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