edoc

The role of self-reactivity in regulatory T cell development and acquisition of diverse regulatory activities

Wyss, Lena. The role of self-reactivity in regulatory T cell development and acquisition of diverse regulatory activities. 2015, PhD Thesis, University of Basel, Faculty of Science.

[img] PDF
Restricted to Repository staff only until 1 December 2017.

12Mb

Official URL: http://edoc.unibas.ch/diss/DissB_11749

Abstract

The importance of regulatory T cells (Tregs) in maintaining lymphocyte homeostasis is best appreciated in mice and humans lacking these cells. FoxP3 KO (scurfy) mice and patients with immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome suffer from excessive lymphocyte activation, lymphocytic infiltration into peripheral organs, and colitis leading to death at an early age. In healthy mice and humans, Tregs control homeostatic proliferation of conventional T and B cells and prevent colitis. Tregs have been classified based on their activation status, expression of surface markers and their ability to migrate to certain tissues. In humans, the proportion of activated and resting Tregs vary with age and the presence immunological disorders. While Tregs have been shown to express self-reactive and foreign-antigen reactive T cell receptors (TCRs), it’s not clear how their antigen specificity determines their regulatory function.
In this study, we identified two Treg cell populations, which are differentially selected, based on their affinity for self-antigens; we further investigate their self- reactivity in vitro and assessed their different regulatory properties using three disease models in vivo.
Advisors:Palmer, Ed and Rolink, Antonius
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Nephrologie > Exp. Transplantationsimmunologie und Nephrologie (Palmer)
Item Type:Thesis
Thesis no:11749
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (126 Seiten
Language:English
Identification Number:
Last Modified:06 Sep 2016 09:00
Deposited On:06 Sep 2016 09:00

Repository Staff Only: item control page