Baumann, Patric Michael. Polymeric nanoreactors for intracellular reactive oxygen species production and mimicking cellular environment. 2015, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_11535
Nanomedicine generally describes the implementation and development of nanotechnology for medical applications. It has a broad range of use, starting from solubilization of specific drug substances, to targeted-delivery systems in a body into a specific tissue or nanoelectronical sensors which are able to detect even the smallest quantities of desired molecules. Nanomedicine aims to support and improve medicine by using properties of nanomaterials in order to diagnose or treat diseases at a molecular level. Especially in cancer therapy nanomedicine has generated a lot of aspiration and visibility. Nanomedicine for cancer therapy for example can improve the transport of a pharmaceutical active substances into the desired tissue, while decreasing the drug substances accumulation in non-target-tissue, additionally drug substances can be protected from degradation and cellular uptake is also facilitated. Materials used for nanomedical approaches rang from natural lipids to modified proteins, antibodies or synthetic polymers. These materials are used to increase the efficacy of various treatments and therefore serve the patients well-being.
To understand therapeutics activities on a nanoscale level and to use nanoscale objects for improving current therapies we focused in this thesis on two different approaches:
i.) Encapsulation of a photoactive molecule in a polymersome to investigate its ability to be used in cancer therapy.
ii.) Encapsulation of an enzyme in a polymersome to study its activity under different crowding condition to mimic a cellular like environment.
|Advisors:||Meier, Wolfgang and Textor, Marcus|
|Faculties and Departments:||05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Online-Ressource|
|Last Modified:||30 Jun 2016 10:59|
|Deposited On:||27 Jan 2016 14:31|
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