Seboek, Dalma and Linscheid, Philippe and Zulewski, Henryk and Langer, Igor and Christ-Crain, Mirjam and Keller, Ulrich and Muller, Beat. (2004) Somatostatin is expressed and secreted by human adipose tissue upon infection and inflammation. Journal of Clinical Endocrinology and Metabolism, 89 (10). pp. 4833-4839.
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Official URL: http://edoc.unibas.ch/dok/A6419837
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Abstract
Somatostatin (SRIF) is a well-known neuroendocrine secretion product. SRIF expression and secretion are induced after inflammation in murine macrophages and in endotoxin-injected sheep and pigs. Because adipocytes have been demonstrated to produce numerous cytokines and peptide hormones, we investigated the expression of SRIF and its receptors (SSTR1-5) in human adipose tissue after inflammatory stimulation in vitro and in tissues from patients with septic disease.Preadipocyte-derived adipocytes, mesenchymal stem cell-derived adipocytes, and mature explanted adipocytes expressed SRIF-mRNA after endotoxin [lipopolysaccharide (LPS)] or IL-1beta treatments. LPS- and IL-1beta-mediated
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller) 03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller) |
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| UniBasel Contributors: | Keller, Ulrich O. and Müller, Beat |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Oxford University Press |
| ISSN: | 0021-972X |
| e-ISSN: | 1945-7197 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 27 Nov 2017 07:30 |
| Deposited On: | 02 Oct 2015 10:00 |
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