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Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man

Berneis, K. and Vosmeer, S. and Keller, U.. (1996) Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. European journal of endocrinology, Vol. 135, H. 6. S. 663-665.

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Official URL: http://edoc.unibas.ch/dok/A6419920

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Abstract

Recent data suggest an involvement of the ob gene and its product leptin in the regulation of body fat. To assess the effects of glucocorticoids and growth hormone (GH) on serum leptin and body fat, 30 normal subjects received methylprednisolone (0.5 mg.kg-1.day-1) per os for 7 days and 15 subjects received in addition sc injections of GH (0.15 IU.kg-1.day-1) twice daily (combination group). Serum leptin levels increased both in the glucocorticoid group (p textless 0.02) and in the combination group (p textless 0.002). When body fat was estimated by bioelectrical impedance analysis it decreased during combined treatment and remained unchanged in the glucocorticoid group. Plasma insulin concentrations increased in both groups. Resting energy expenditure (indirect calorimetry) increased in the combination group and remained unchanged in the glucocorticoid group. The finding of increased serum leptin concentrations during treatment with glucocorticoid and GH suggests that serum leptin is regulated by glucocorticoids, possibly though changes in insulin secretion, independently of changes of body fat mass.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
UniBasel Contributors:Keller, Ulrich O.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:BioScientifica
ISSN:0804-4643
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:02 Oct 2015 10:00
Deposited On:02 Oct 2015 10:00

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