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Calixarene-based amphiphiles : synthesis, self-assembly and interaction with DNA

Rullaud, Vanessa. Calixarene-based amphiphiles : synthesis, self-assembly and interaction with DNA. 2015, PhD Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_11453

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Abstract

The present doctoral thesis focused on the synthesis of amphiphilic calix[4]arenes, the study of their self-assembly properties at the air-water interface as Langmuir monolayers or in solution as nanoparticles and on the DNA-binding properties of the resulting self-assembled structures. The objective is to improve the understanding of the interaction of amphiphilic calixarene-based nanoparticles with DNA molecules, and to improve the comprehension of the effect of the calixarene structure: on the self-assembly of the amphiphilic calixarene as nanoparticles and on the interaction of the calixarene-based nanoparticles with DNA.
The results reported in my PhD dissertation highlight the influence of the calixarene structure, on their self-assembly as Langmuir monolayer at the air-water interface and as nanoparticles in water. Moreover the binding mechanism between the DNA phospho-diester backbone and the self-assembled calix[4]arene is dependent of the number of recognition moieties but is also governed by a sequence dependent interaction mechanism.
Advisors:Shahgaldian, Patrick
Committee Members:Ward, Thomas R. and Meier, Wolfgang Peter
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
Item Type:Thesis
Thesis no:11453
Bibsysno:Link to catalogue
Number of Pages:183 S.
Language:English
Identification Number:
Last Modified:30 Jun 2016 10:58
Deposited On:02 Nov 2015 14:12

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