Hartmann, Francina. Hormonal and genetic modulation of memory processes in healthy humans: focus on cortisol and "HDAC5". 2015, PhD Thesis, University of Basel, Faculty of Psychology.
Official URL: http://edoc.unibas.ch/diss/DissB_11297
To investigate if stress, induced by the cold pressor test, affects memory processes, a fear-conditioning paradigm was used. The stress group showed an increase in the cortisol level and reduced retrieval of the conditioned fear memory. In a further study, we investigated if inter-individual changes in basal cortisol levels affect episodic memory. Results showed an association between stronger decreases in cortisol levels during retrieval and a better recall performance.
In a large genetic study we focused on genetic polymorphisms tagging histone deacetylase 5 (HDAC5), a gene associated with synaptic plasticity and memory formation in animal models. We detected significant associations between these polymorphisms and episodic memory performance, especially for emotional information. Surprisingly, these polymorphisms were strongly associated with expression levels of a transcript in the vicinity of HDAC5.
These results may have implications for the understanding of the mechanisms underlying memory formation in healthy subjects and the interpretation of genetic data. Additionally, our results may have clinical implications for different neuropsychiatric disorders, such as depression, anxiety disorders or posttraumatic stress disorder, for which learning and memory play an important role.
|Committee Members:||Quervain, Dominique de|
|Faculties and Departments:||07 Faculty of Psychology > Departement Psychologie > Abteilung Molecular Psychology > Molecular Psychology (Papassotiropoulos)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 vol.|
|Last Modified:||30 Jun 2016 10:58|
|Deposited On:||12 Aug 2015 14:01|
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