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Simple "on-demand" production of bioactive natural products

Bode, Edna and Brachmann, Alexander O. and Kegler, Carsten and Simsek, Rukayye and Dauth, Christina and Zhou, Qiuqin and Kaiser, Marcel and Klemmt, Petra and Bode, Helge B.. (2015) Simple "on-demand" production of bioactive natural products. ChemBioChem, Vol. 16, H. 7. S. 1115-1119.

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Official URL: http://edoc.unibas.ch/dok/A6381859

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Abstract

Exchange of the native promoter to the arabinose-inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the "on-demand" production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel "mevalagmapeptides" and the highly toxic xenorhabdins were identified by this approach.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Wiley-VCH
ISSN:1439-4227
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Jun 2015 08:52
Deposited On:05 Jun 2015 08:52

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