Pivetta, Chiara. Organization and connectivity of spinal ascending pathways reporting to brainstem. 2015, PhD Thesis, University of Basel, Faculty of Science.
Restricted to Repository staff only until 1 January 2019.
Official URL: http://edoc.unibas.ch/diss/DissB_11288
I will present the result of my studies on the organization of spinal ascending pathways signaling information to the lateral reticular nucleus (LRN) in the brainstem using a newly-developed mouse genetic tool intersectionally with viruses. I will focus on : (1) the organization of forelimb premotors signaling information to the LRN, (2) their developmental origin and (3) the organization of spinal premotor and non-premotor input to the LRN. In the following chapters, I will also present preliminary behavioral data on the role of the LRN in reaching behavior before and after the learning of the motor task, as well as on the inhibitory inputs to spinocerebellar neurons in the lumbar spinal cord and differences among them.
The last part of my thesis concerns my contribution to the project of Cyrill Goetz. The aim is to elucidate the structural organization and composition of premotor neurons controlling muscles with distinct biomechanical functions, axial- versus limb muscles. I will show the results obtained in the premotor distribution of axial muscle innervating motor neurons and my contribution in corroborating these findings by means of an anterograde viral approach.
|Committee Members:||Scheiffele, Peter|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)|
|Bibsysno:||Link to catalogue|
|Last Modified:||30 Jun 2016 10:57|
|Deposited On:||03 Aug 2015 13:28|
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