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Plasmodium gene regulation : far more to factor in

Llinás, Manuel and Deitsch, Kirk W. and Voss, Till S.. (2008) Plasmodium gene regulation : far more to factor in. Trends in parasitology, Vol. 24, H. 12. S. 551-556.

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Official URL: http://edoc.unibas.ch/dok/A6357833

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Abstract

Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variation and host immune evasion. However, the role of transcriptional regulation in governing other genes expressed during the various stages of development has remained less well characterized. This mostly has been due to the lack of defined transcriptional regulators in Plasmodium parasites. Here, we describe recent advances that have become possible by joining traditional biochemistry with new technological innovations. These studies have increased our understanding of the role of transcriptional regulation, not only in the control of gene expression for antigenic variation but also in the coordination of stage-specific parasite development.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Gene Regulation (Voss)
UniBasel Contributors:Voss, Till S
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:13
Deposited On:10 Apr 2015 09:13

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