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The types and prevalence of alternative splice forms

Zavolan, M. and van Nimwegen, E.. (2006) The types and prevalence of alternative splice forms. Current opinion in structural biology, Vol. 16, H. 3. S. 362-367.

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Official URL: http://edoc.unibas.ch/dok/A5259663

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Abstract

The finding that eukaryotic gene structures are extremely complex prompted the development of new experimental techniques for the accurate measurement of transcription start site usage and of the expression of alternative splice forms. On the computational side, analyses of large databases of splice variants revealed differences in the length, motif composition and selection pressure between constitutive and alternatively spliced exons. Such features are being incorporated into novel computational tools for gene structure prediction. The result of these investigations is a continuously improving catalogue of alternative splice forms. How the expression of these alternative splice forms is regulated remains one of the major open questions.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (van Nimwegen)
05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
UniBasel Contributors:van Nimwegen, Erik and Zavolan, Mihaela
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Current Biology
ISSN:0959-440X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 06:50
Deposited On:22 Mar 2012 13:23

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