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Adult lung function and long-term air pollution exposure : ESCAPE : a multicentre cohort study and meta-analysis

Adam, Martin and Schikowski, Tamara and Carsin, Anne Elie and Cai, Yutong and Jacquemin, Benedicte and Sanchez, Margaux and Vierkötter, Andrea and Marcon, Alessandro and Keidel, Dirk and Sugiri, Dorothee and Al Kanani, Zaina and Nadif, Rachel and Siroux, Valérie and Hardy, Rebecca and Kuh, Diana and Rochat, Thierry and Bridevaux, Pierre-Olivier and Eeftens, Marloes and Tsai, Ming-Yi and Villani, Simona and Phuleria, Harish Chandra and Birk, Matthias and Cyrys, Josef and Cirach, Marta and de Nazelle, Audrey and Nieuwenhuijsen, Mark J. and Forsberg, Bertil and de Hoogh, Kees and Declerq, Christophe and Bono, Roberto and Piccioni, Pavilio and Quass, Ulrich and Heinrich, Joachim and Jarvis, Deborah and Pin, Isabelle and Beelen, Rob and Hoek, Gerard and Brunekreef, Bert and Schindler, Christian and Sunyer, Jordi and Krämer, Ursula and Kauffmann, Francine and Hansell, Anna L. and Künzli, Nino and Probst-Hensch, Nicole. (2015) Adult lung function and long-term air pollution exposure : ESCAPE : a multicentre cohort study and meta-analysis. The European respiratory journal, Vol. 45, H. 1. S. 38-50.

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Official URL: http://edoc.unibas.ch/dok/A6337702

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Abstract

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Exposure Science (Tsai)
UniBasel Contributors:Adam, Martin and Schikowski, Tamara and Keidel, Dirk and Eeftens, Marloes and Tsai, Ming and Phuleria, Harish Chandra and de Hoogh, Kees and Schindler, Christian and Künzli, Nino and Probst Hensch, Nicole
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Feb 2015 09:59
Deposited On:06 Feb 2015 09:59

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