Shanker, Vijay. Protein phosphatase 2A inhibits interferon signaling through the Jak STAT pathway and promotes hepatitis C viral replication. 2014, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_10966
The selective behavior of PP2A for Jak-STAT1 signaling pathway inhibition and promotion of HCV replication could be due to the targeted substrate selection by PP2A holoenzyme complex. In the second part of this work, attempts were made to determine the specific regulatory B subunits involved in IFN-α induced Jak-STAT1 signaling inhibition and HCV replication. We observed the inter-regulatory behavior of PP2A subunits. During the course of this study, due to unavailability of specific antibodies for various isoforms of B subunit, the aim to determine specific holoenzyme complex involved in regulation of Jak-STAT1 signaling and HCV replication was not achieved.
Further studies are required to investigate the specific B subunits and thereby holoenzyme complex responsible for IFN-α induced Jak-STAT signaling inhibition and HCV replication by PP2A.
|Advisors:||Heim, Markus Hermann|
|Committee Members:||Wymann, Matthias Paul|
|Faculties and Departments:||03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Hepatology Laboratory (Heim)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||91 p.|
|Last Modified:||30 Jun 2016 10:56|
|Deposited On:||03 Nov 2014 12:43|
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