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High genetic diversity of Plasmodium vivax on the North Coast of Papua New Guinea

Arnott, Alicia and Barnadas, Celine and Senn, Nicolas and Siba, Peter and Mueller, Ivo and Reeder, John C. and Barry, Alyssa E.. (2013) High genetic diversity of Plasmodium vivax on the North Coast of Papua New Guinea. American journal of tropical medicine and hygiene, Vol. 89, H. 1. S. 188-194.

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Official URL: http://edoc.unibas.ch/dok/A6164954

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Abstract

Abstract. Despite having the highest Plasmodium vivax burden in the world, molecular epidemiological data from Papua New Guinea (PNG) for this parasite remain limited. To investigate the molecular epidemiology of P. vivax in PNG, 574 isolates collected from four catchment sites in East Sepik (N = 1) and Madang (N = 3) Provinces were genotyped using the markers MS16 and msp1F3. Genetic diversity and prevalence of P. vivax was determined for all sites. Despite a P. vivax infection prevalence in the East Sepik (15%) catchments less than one-half the prevalence of the Madang catchments (27-35%), genetic diversity was similarly high in all populations (He = 0.77-0.98). High genetic diversity, despite a marked difference in infection prevalence, suggests a large reservoir of diversity in P. vivax populations of PNG. Significant reductions in transmission intensity may, therefore, be required to reduce the diversity of parasite populations in highly endemic countries such as PNG.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Interventions (Lengeler)
UniBasel Contributors:Senn, Nicolas
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Jul 2014 09:09
Deposited On:18 Jul 2014 09:09

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