edoc

Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt

Altmann, Danny and Aseffa, Abraham and Bash, Margaret and Basta, Nicole and Borrow, Ray and Broome, Claire and Caugant, Dominique and Clark, Tom and Collard, Jean-Marc and Djingarey, Mamoudou and Goldblatt, David and Greenwood, Brian and Griffiths, Ulla and Hajjeh, Rana and Hassan-King, Musa and Hugonnet, Stephane and Kimball, Ann Marie and LaForce, Marc and MacLennan, Calman and Maiden, Martin C. J. and Manigart, Olivier and Mayer, Leonard and Messonnier, Nancy and Moisi, Jennifer and Moore, Katie and Moto, Daugla Doumagoum and Mueller, Judith and Nascimento, Maria and Obaro, Stephen and Ouedraogo, Rasmata and Page, Anne-Laure and Perea, Willima and Pluschke, Gerd and Preziosi, Mari-Pierre and Sow, Samba and Stephens, David and Stuart, James and Thomson, Madeleiene and Tiendrebeogo, Sylvestre and Trape, Jean-Francois and Vernet, Guy. (2013) Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt. Vaccine : the official journal of the International Society for Vaccines, Vol. 31, H. 11. S. 1453-1457.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6223351

Downloads: Statistics Overview

Abstract

For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main approach to the control of these epidemics has been reactive vaccination with a polysaccharide vaccine after an outbreak has reached a defined threshold and provision of easy access to effective treatment but this approach has not prevented the occurrence of new epidemics. Meningococcal conjugate vaccines, which can prevent meningococcal carriage and thus interrupt transmission, may be more effective than polysaccharide vaccines at preventing epidemics. Because the majority of African epidemics have been caused by serogroup A meningococci, a serogroup A polysaccharide/tetanus toxoid protein conjugate vaccine (PsA-TT) has recently been developed. Results from an initial evaluation of the impact of this vaccine on meningococcal disease and meningococcal carriage in Burkina Faso have been encouraging. To review how the research agenda for meningococcal disease in Africa has been changed by the advent of PsA-TT and to define a new set of research priorities for study of meningococcal infection in Africa, a meeting of 41 scientists was held in Dakar, Senegal on April 24th and 25th 2012. The research recommendations developed during the course of this meeting are presented in this paper. The need for enhanced surveillance for meningitis in defined populations with good diagnostic facilities in African countries at risk of epidemics was identified as the highest priority. This is needed to determine the duration of protection against serogroup A meningococcal disease provided by PsA-TT and to determine the risk of disease and carriage caused by meningococci of other serogroups. Other research areas given high priority included identification and validation of serological correlates of protection against meningococcal disease and carriage, development of improved method for detecting carriage and epidemiological studies aimed at determining the reasons underlying the peculiar epidemiology of meningococcal disease in the African meningitis belt. Minutes and working papers from the meeting are provided in supplementary tables and some of the presentations made at the meeting are available on the MenAfriCar consortium website (www.menafricar.org) and on the web site of the Centers for Disease Control (www.cdc.gov).
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier ; [Online:] Amsterdam
ISSN:0264-410X
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

Repository Staff Only: item control page