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ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools

Livet, J. and Sigrist, M. and Stroebel, S. and De Paola, V. and Price, S. R. and Henderson, C. E. and Jessell, T. M. and Arber, S.. (2002) ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron, Vol. 35, H. 5. S. 877-892.

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Official URL: http://edoc.unibas.ch/dok/A5259089

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Abstract

The projection of developing axons to their targets is a crucial step in the assembly of neuronal circuits. In the spinal cord, the differentiation of specific motor neuron pools is associated with the expression of ETS class transcription factors, notably PEA3 and ER81. Their initial expression coincides with the arrival of motor axons in the vicinity of muscle targets and depends on limb-derived signals. We show that in Pea3 mutant mice, the axons of specific motor neuron pools fail to branch normally within their target muscles, and the cell bodies of these motor neurons are mispositioned within the spinal cord. Thus, the induction of an intrinsic program of ETS gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0896-6273
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:21

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