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Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

Comas, Iñaki and Coscolla, Mireia and Luo, Tao and Borrell, Sonia and Holt, Kathryn E. and Kato-Maeda, Midori and Parkhill, Julian and Malla, Bijaya and Berg, Stefan and Thwaites, Guy and Yeboah-Manu, Dorothy and Bothamley, Graham and Mei, Jian and Wei, Lanhai and Bentley, Stephen and Harris, Simon R. and Niemann, Stefan and Diel, Roland and Aseffa, Abraham and Gao, Qian and Young, Douglas and Gagneux, Sebastien. (2013) Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nature genetics, Vol. 45, H. 10. S. 1176-1182.

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Official URL: http://edoc.unibas.ch/dok/A6183881

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Abstract

Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Gagneux, Sebastien and Borrell, Sonia and Coscollá, Mireja
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Nature Publ
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Feb 2014 15:46
Deposited On:27 Feb 2014 15:46

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