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Deletion of the murine scavenger receptor CD68

Song, Li and Lee, Carolyn and Schindler, Christian. (2011) Deletion of the murine scavenger receptor CD68. Journal of lipid research, Vol. 52, H. 8. S. 1542-1550.

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Official URL: http://edoc.unibas.ch/dok/A6004139

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Abstract

Scavenger receptors (ScRs) are a structurally unrelated family of receptors with the ability to bind modified low density lipoprotein (LDL) as well as a broad range of polyanionic ligands. CD68, whose expression is restricted to mononuclear phagocytes, is a unique ScR family member, owing to its lysosome associated membrane protein (LAMP)-like domain and predominant endosomal distribution. Knockout (ko) mice were generated to directly evaluate the role murine CD68 may play in oxidized LDL (Ox-LDL) uptake. However, CD68?/? macrophages took up Ox-LDL robustly. Likewise, no defects were observed in the ability of CD68?/? mononuclear phagocytes to take up or mount an effective innate response against a number of microbes. Curiously, CD68?/? mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4? T-cells, raising the possibility that CD68 may function either to negatively regulate antigen uptake, loading, or major histocompatibility complex class II (MHC-II) trafficking.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
UniBasel Contributors:Schindler, Christian
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Lipid Research
ISSN:0022-2275
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Feb 2014 15:45
Deposited On:27 Feb 2014 15:45

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