Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Artigas, M. S. and Loth, D. W. and Wain, L. V. and Gharib, S. A. and Obeidat, M. and Tang, W. and Zhai, G. and Zhao, J. H. and Smith, A. V. and Huffman, J. E. and Albrecht, E. and Jackson, C. M. and Evans, D. M. and Cadby, G. and Fornage, M. and Manichaikul, A. and Lopez, L. M. and Johnson, T. and Aldrich, M. C. and Aspelund, T. and Barroso, I. and Campbell, H. and Cassano, P. A. and Couper, D. J. and Eiriksdottir, G. and Franceschini, N. and Garcia, M. and Gieger, C. and Gislason, G. K. and Grkovic, I. and Hammond, C. J. and Hancock, D. B. and Harris, T. B. and Ramasamy, A. and Heckbert, S. R. and Heliovaara, M. and Homuth, G. and Hysi, P. G. and James, A. L. and Jankovic, S. and Joubert, B. R. and Karrasch, S. and Klopp, N. and Koch, B. and Kritchevsky, S. B. and Launer, L. J. and Liu, Y. and Loehr, L. R. and Lohman, K. and Loos, R. J. and Lumley, T. and Al Balushi K. A., and Ang, W. Q. and Barr, R. G. and Beilby, J. and Blakey, J. D. and Boban, M. and Boraska, V. and Brisman, J. and Britton, J. R. and Brusselle, G. G. and Cooper, C. and Curjuric, I. and Dahgam, S. and Deary, I. J. and Ebrahim, S. and Eijgelsheim, M. and Francks, C. and Gaysina, D. and Granell, R. and Gu, X. and Hankinson, J. L. and Hardy, R. and Harris, S. E. and Henderson, J. and Henry, A. and Hingorani, A. D. and Hofman, A. and Holt, P. G. and Hui, J. and Hunter, M. L. and Imboden, M. and Jameson, K. A. and Kerr, S. M. and Kolcic, I. and Kronenberg, F. and Liu, J. Z. and Marchini, J. and McKeever, T. and Morris, A. D. and Olin, A. C. and Porteous, D. J. and Postma, D. S. and Rich, S. S. and Ring, S. M. and Rivadeneira, F. and Rochat, T. and Sayer, A. A. and Sayers, I. and Sly, P. D. and Smith, G. D. and Sood, A. and Starr, J. M. and Uitterlinden, A. G. and Vonk, J. M. and Wannamethee, S. G. and Whincup, P. H. and Wijmenga, C. and Williams, O. D. and Wong, A. and Mangino, M. and Marciante, K. D. and McArdle, W. L. and Meibohm, B. and Morrison, A. C. and North, K. E. and Omenaas, E. and Palmer, L. J. and Pietilainen, K. H. and Pin, I. and Pola Sbreve E. O., and Pouta, A. and Psaty, B. M. and Hartikainen, A. L. and Rantanen, T. and Ripatti, S. and Rotter, J. I. and Rudan, I. and Rudnicka, A. R. and Schulz, H. and Shin, S. Y. and Spector, T. D. and Surakka, I. and Vitart, V. and Volzke, H. and Wareham, N. J. and Warrington, N. M. and Wichmann, H. E. and Wild, S. H. and Wilk, J. B. and Wjst, M. and Wright, A. F. and Zgaga, L. and Zemunik, T. and Pennell, C. E. and Nyberg, F. and Kuh, D. and Holloway, J. W. and Boezen, H. M. and Lawlor, D. A. and Morris, R. W. and Probst-Hensch N., and Kaprio, J. and Wilson, J. F. and Hayward, C. and Kahonen, M. and Heinrich, J. and Musk, A. W. and Jarvis, D. L. and Glaser, S. and Jarvelin, M. R. and Ch Stricker B. H., and Elliott, P. and O'Connor G. T., and Strachan, D. P. and London, S. J. and Hall, I. P. and Gudnason, V. and Tobin, M. D.. (2011) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature genetics, Vol. 43, H. 11. S. 1082-1090.

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Official URL: http://edoc.unibas.ch/dok/A6002216

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Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P > 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Nature Publ.
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Feb 2014 15:45
Deposited On:27 Feb 2014 15:45

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