edoc

Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius

Bringmann, Gerhard and Zhang, Guoliang and Olschläger, Tobias and Stich, August and Wu, Jun and Chatterjee, Manik and Brun, Reto. (2013) Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry : an international journal of plant biochemistry, Vol. 91. S. 220-228.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6164981

Downloads: Statistics Overview

Abstract

Naphthylisoquinoline alkaloids, named ancistectorine A1, N-methylancistectorine A1, ancistectorine A2, 5-epi-ancistectorine A2, ancistectorine A3, ancistectorine B1, and ancistectorine C1, have been isolated from twigs of the Chinese plant Ancistrocladus tectorius. The structural elucidation succeeded by chemical, spectroscopic, and chiroptical methods. Three of these compounds exhibited excellent, and specific, antiplasmodial activities, comparable with that of the as yet most active representative, dioncophylline C. Moreover, the antitumoral activities of two of the main alkaloids in this species was tested.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0031-9422
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:31 Jan 2014 09:49
Deposited On:31 Jan 2014 09:49

Repository Staff Only: item control page