Donato, Flavio. Microcircuit remodeling processes underlying learning in the adult. 2013, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_10613
Here, I explore how the remodeling of identified microcircuits in the mouse hippocampus and neocortex supports learning in the adult.
In the first part, I identifiy a microcircuit module engaging VIP and Parvalbumin (PV) positive interneurons to regulate the state of the PV+ network upon experience. This defines states of enhanced or reduced structural plasticity and learning based on the distribution of PV intensity in the network.
In the second part, I demonstrate how specific hippocampal subdivisions are exploited to learn subtasks of trial-and-errors forms of learning via the deployment of increasingly precise searching strategies, and sequential recruitment of ventral, intermediate, and dorsal hippocampus.
In the third part, I highlight the existence of genetically matched subpopulations of principal cells in the hippocampus, which achieve selective connectivity across hippocampal subdivisions via matched windows of neurogenesis and synaptogenesis during development.
In the fourth part, I investigate the maturation of microcircuits mediating feedforward inhibition in the hippocampus, and highlight windows during development for the establishment of the proper baseline configuration in the adult. Moreover, I identify a critical window for cognitive enhancement during hippocampal development.
In the fifth part, I study how ageing affects the PV network in hippocampal CA3, providing evidence for which age related neuronal loss correlates to reduced incidental learning performances in old mice. Therefore, by manipulating the PV network early during life, I provide strategies to modulate cognitive decline.
|Committee Members:||Arber, Silvia|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||261 S.|
|Last Modified:||30 Jun 2016 10:54|
|Deposited On:||09 Dec 2013 16:09|
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