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Evidence against inhibition of the renin-angiotensinogen reaction by des-angiotensin substrate in the rat

Hackenthal, E. and Hackenthal, R. and Hofbauer, K. G.. (1976) Evidence against inhibition of the renin-angiotensinogen reaction by des-angiotensin substrate in the rat. Clinical Science and Molecular Medicine. Supplement, 3 , S. 155s-157s.

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Official URL: http://edoc.unibas.ch/dok/A5258691

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Abstract

1. The possible inhibitory effect of des-angiotensin I substrate on the renin-substrate reaction was studied. For this purpose rat angiotensinogen was purified 50-fool from plasma of nephrectomized rats. Des-angiotensin substrate was prepared from the purified angiotensinogen preparation by reaction with immobilized hog renin (coupled to Sepharose). 2. In kinetic experiments it was found that desangiotensin I substrate in concentrations of 0-225 and 0-45 micronmol/l has no influence on the reaction between rat renin and rat angiotensinogen.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0144-4107
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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