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Is the natriuretic effect of atrial natriuretic factor in conscious rats mediated by renal vasodilatation?

Sonnenburg, C. and Muir, A. C. and Criscione, L. and Kraetz, J. and Hofbauer, K. G.. (1985) Is the natriuretic effect of atrial natriuretic factor in conscious rats mediated by renal vasodilatation? Journal of Hypertension, Vol. 3, H. 3 , S303-S305.

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Official URL: http://edoc.unibas.ch/dok/A5258664

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Abstract

Atrial natriuretic factors (ANF) have both vasorelaxant and natriuretic properties. It has been suggested that their effects on sodium excretion depend on renal vasodilatation. We studied the haemodynamic (ultrasound Doppler flow probes) effects of synthetic atriopeptin II at natriuretic doses in conscious rats. Intravenous injections of atriopeptin II induced a marked, dose-dependent increase in sodium excretion. This was accompanied by a slight reduction in blood pressure (BP) and a transient decrease in renal, mesenteric and aortic blood flow. In contrast, a selective renal vasodilator, CGP 22,979, induced a moderate increase in sodium excretion concomitantly with a rise in renal blood flow. Blood pressure and the other regional flows remained unchanged. These findings suggest that the natriuretic effect of CGP 22,979 is closely related to an increased renal blood flow. Conversely, the natriuresis induced by atriopeptin II is not accompanied by selective renal vasodilatation and appears to be due either to a tubular action or to changes in intrarenal haemodynamics.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0263-6352
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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