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Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

Baker, Nicola and de Koning, Harry P. and Mäser, Pascal and Horn, David. (2013) Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology, Vol. 29, H. 3. S. 110-118.

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Official URL: http://edoc.unibas.ch/dok/A6124532

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Abstract

Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat the diseases caused by African trypanosomes: sleeping sickness in humans and Nagana in livestock. Cross-resistance to these drugs was first observed over 60 years ago and remains the only example of cross-resistance among sleeping sickness therapies. A Trypanosoma brucei adenosine transporter is well known for its role in the uptake of both drugs. More recently, aquaglyceroporin 2 (AQP2) loss of function was linked to melarsoprol-pentamidine cross-resistance. AQP2, a channel that appears to facilitate drug accumulation, may also be linked to clinical cases of resistance. Here, we review these findings and consider some new questions as well as future prospects for tackling the devastating diseases caused by these parasites.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Mäser, Pascal
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:32

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