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Synthesis of a potent antimalarial agent through natural products conjugation

Bruno, M. and Trucchi, B. and Monti, D. and Romeo, S. and Kaiser, M. and Verotta, L.. (2013) Synthesis of a potent antimalarial agent through natural products conjugation. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 2. S. 221-225.

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Official URL: http://edoc.unibas.ch/dok/A6094399

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Abstract

Au naturel! (+)-Usnic acid (green) is a weak antimalarial agent, however, in conjugation with known antimalarial scaffolds and drugs, such as dihydroartemisinin (blue), potent activity against the blood-stage parasite can be seen both in vitro and in vivo. The compound shown exhibits an IC(50) value of 1.4 nM against Plasmodium falciparum in vitro and proved nearly as efficacious as artesunate in a mouse model of infection
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Wiley-VCH
ISSN:1860-7179
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:31

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