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Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee

Coscolla, Mireia and Lewin, Astrid and Metzger, Sonja and Maetz-Rennsing, Kerstin and Calvignac-Spencer, Sébastien and Nitsche, Andreas and Dabrowski, Pjotr Wojtek and Radonic, Aleksandar and Niemann, Stefan and Parkhill, Julian and Couacy-Hymann, Emmanuel and Feldman, Julia and Comas, Iñaki and Boesch, Christophe and Gagneux, Sebastien and Leendertz, Fabian H.. (2013) Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee. Emerging infectious diseases, Vol. 19, H. 6. S. 969-976.

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Official URL: http://edoc.unibas.ch/dok/A6146294

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Abstract

Tuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild animal species. We report an M. tuberculosis strain isolated from a wild chimpanzee in Côte d'Ivoire that was shown by comparative genomic and phylogenomic analyses to belong to a new lineage of MTBC, closer to the human-associated lineage 6 (also known as M. africanum West Africa 2) than to the other classical animal-associated MTBC strains. These results show that the general view of the genetic diversity of MTBC is limited and support the possibility that other MTBC variants exist, particularly in wild mammals in Africa. Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Coscollá, Mireja and Gagneux, Sebastien
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:National Center for Infectious Diseases
ISSN:1080-6040
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:30

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