edoc

Stammzelltherapie bei Autoimmunerkrankungen = Stem cell treatment of autoimmune disease

Daikeler, T. and Tyndall, A.. (2011) Stammzelltherapie bei Autoimmunerkrankungen = Stem cell treatment of autoimmune disease. Deutsche medizinische Wochenschrift, Jg. 136, H. 33. S. 1684-1686.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007416

Downloads: Statistics Overview

Abstract

Over 1,500 patients world wide have received a hematopoietic stem cell transplant (HSCT) as treatment for a severe autoimmune disease. Most of these have been autologous and mostly have occurred in the past 15 years. Over 1,000 of these have been registered in the European Group for Bone Marrow Transplantation (EBMT) and European League Against Rheumatism (EULAR) combined data base. A recent retrospective analysis of 900 patients (1) showed that the majority had multiple sclerosis (n?=?345) followed by systemic sclerosis (n?=?175), systemic lupus erythematosus (n?=?85), rheumatoid arthritis (n?=?89), juvenile idiopathic arthritis (n?=?65) and idiopathic cytopenic purpura (n?=?37). An overall 85?% 5-year-survival and 43?% progression-free survival was seen, with 100-day-transplant-related-mortality (TRM) ranging between 1?% (rheumatoid arthritis) and 11?% (systemic lupus erythematosus and juvenile idiopathic arthritis). Around 30?% of patients in all disease subgroups had a complete response, often durable despite full immune reconstitution. In many, e.?g. systemic sclerosis, morphological improvement such as reduction of skin collagen and normalisation of microvasculature was documented, beyond any predicted known effects of intense immunosuppression alone. The high TRM was in part related to conditioning intensity, comorbidity and age, and the final risk/benefit assessment will be made after the results of the three randomised propective clinical trials are known. [nl]Recently, multipotent mesenchymal stromal cells have been tested in various autoimmune diseases, exploiting their immune modulating properties and apparent low acute toxicity. Despite encouraging small phase I/II studies, no positive data from randomised, prospective studies are as yet available in the peer reviewed literature.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Rheumatologie FPS (Tyndall)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Rheumatologie FPS (Tyndall)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Rheumatologie FPS (Tyndall)
UniBasel Contributors:De Vere-Tyndall, Alan and Daikeler, Thomas
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Georg Thieme Verlag
ISSN:0012-0472
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:18 Jul 2014 09:10
Deposited On:19 Jul 2013 07:35

Repository Staff Only: item control page