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Hyponatriämie

Scheuter, Claudia and Rutishauser, Jonas. (2011) Hyponatriämie. Therapeutische Umschau, Vol. 68, H. 6. S. 327-336.

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Official URL: http://edoc.unibas.ch/dok/A6007736

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Abstract

Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased mortality in hospitalized patients. Sodium is the predominant extracellular cation and, together with its anion chloride, constitutes most of the osmoles in the extracellular space. In the presence of an intact thirst sensation, serum osmolality is set by the mechanisms of salt and water homeostasis to ~280-290 mOsm/kg. Hyponatremia results from excess of free water more often than from lack of salt. Free water clearance is regulated by the antidiuretic hormone and depends on adequate delivery of solute to the diluting segments of the nephron. Analysis of hyponatremia is best performed in a systematic manner, taking into account measured or calculated serum osmolality and the volume state as assessed clinically. Urinary osmolality and sodium concentration may facilitate the differential diagnosis. Therapy of hyponatremia should aim at correcting the underlying disorder. Only in severe, symptomatic hyponatremia should hypertonic saline be infused, in which case care should be taken to avoid complications such as osmotic demyelination.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie
UniBasel Contributors:Rutishauser, Jonas
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Hans Huber
ISSN:0040-5930
Note:Note: Englischer Titel: Hyponatremia -- Publication type according to Uni Basel Research Database: Journal item
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:24

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