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Clonal groupings in serogroup X Neisseria meningitidis

Gagneux, Sébastien and Wirth, Thierry and Hodgson, Abraham and Ehrhard, Ingrid and Morelli, Giovanna and Kriz, Paula and Genton, Blaise and Smith, Tom and Binka, Fred and Pluschke, Gerd and Achtman, Mark. (2002) Clonal groupings in serogroup X Neisseria meningitidis. Emerging Infectious Diseases, Vol. 8, H. 5. S. 462-466.

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Official URL: http://edoc.unibas.ch/dok/A6124421

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Abstract

The genetic diversity of 134 serogroup X Neisseria meningitis isolates from Africa, Europe, and North America was analyzed by multilocus sequence typing and pulsed-field gel electrophoresis. Although most European and American isolates were highly diverse, one clonal grouping was identified in sporadic disease and carrier strains isolated over the last 2 decades in the United Kingdom, the Netherlands, Germany, and the United States. In contrast to the diversity in the European and American isolates, most carrier and disease isolates recovered during the last 30 years in countries in the African meningitis belt belonged to a second clonal grouping. During the last decade, these bacteria have caused meningitis outbreaks in Niger and Ghana. These results support the development of a comprehensive conjugate vaccine that would include serogroup X polysaccharide.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Gagneux, Sebastien
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:National Center for Infectious Diseases
ISSN:1080-6040
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:23
Deposited On:24 May 2013 09:19

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