edoc

New loci associated with kidney function and chronic kidney disease

Köttgen, Anna and Pattaro, Cristian and Böger, Carsten A. and Fuchsberger, Christian and Olden, Matthias and Glazer, Nicole L. and Parsa, Afshin and Gao, Xiaoyi and Yang, Qiong and Smith, Albert V. and O'Connell, Jeffrey R. and Li, Man and Schmidt, Helena and Tanaka, Toshiko and Isaacs, Aaron and Ketkar, Shamika and Hwang, Shih-Jen and Johnson, Andrew D. and Dehghan, Abbas and Teumer, Alexander and Paré, Guillaume and Atkinson, Elizabeth J. and Zeller, Tanja and Lohman, Kurt and Cornelis, Marilyn C. and Probst-Hensch, Nicole M. and Kronenberg, Florian and Tönjes, Anke and Hayward, Caroline and Aspelund, Thor and Eiriksdottir, Gudny and Launer, Lenore J. and Harris, Tamara B. and Rampersaud, Evadnie and Mitchell, Braxton D. and Arking, Dan E. and Boerwinkle, Eric and Struchalin, Maksim and Cavalieri, Margherita and Singleton, Andrew and Giallauria, Francesco and Metter, Jeffrey and de Boer, Ian H. and Haritunians, Talin and Lumley, Thomas and Siscovick, David and Psaty, Bruce M. and Zillikens, M. Carola and Oostra, Ben A. and Feitosa, Mary and Province, Michael and de Andrade, Mariza and Turner, Stephen T. and Schillert, Arne and Ziegler, Andreas and Wild, Philipp S. and Schnabel, Renate B. and Wilde, Sandra and Munzel, Thomas F. and Leak, Tennille S. and Illig, Thomas and Klopp, Norman and Meisinger, Christa and Wichmann, H-Erich and Koenig, Wolfgang and Zgaga, Lina and Zemunik, Tatijana and Kolcic, Ivana and Minelli, Cosetta and Hu, Frank B. and Johansson, Asa and Igl, Wilmar and Zaboli, Ghazal and Wild, Sarah H. and Wright, Alan F. and Campbell, Harry and Ellinghaus, David and Schreiber, Stefan and Aulchenko, Yurii S. and Felix, Janine F. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Hofman, Albert and Imboden, Medea and Nitsch, Dorothea and Brandstätter, Anita and Kollerits, Barbara and Kedenko, Lyudmyla and Mägi, Reedik and Stumvoll, Michael and Kovacs, Peter and Boban, Mladen and Campbell, Susan and Endlich, Karlhans and Völzke, Henry and Kroemer, Heyo K. and Nauck, Matthias and Völker, Uwe and Polasek, Ozren and Vitart, Veronique and Badola, Sunita and Parker, Alexander N. and Ridker, Paul M. and Kardia, Sharon L. R. and Blankenberg, Stefan and Liu, Yongmei and Curhan, Gary C. and Franke, Andre and Rochat, Thierry and Paulweber, Bernhard and Prokopenko, Inga and Wang, Wei and Gudnason, Vilmundur and Shuldiner, Alan R. and Coresh, Josef and Schmidt, Reinhold and Ferrucci, Luigi and Shlipak, Michael G. and van Duijn, Cornelia M. and Borecki, Ingrid and Krämer, Bernhard K. and Rudan, Igor and Gyllensten, Ulf and Wilson, James F. and Witteman, Jacqueline C. and Pramstaller, Peter P. and Rettig, Rainer and Hastie, Nick and Chasman, Daniel I. and Kao, W. H. and Heid, Iris M. and Fox, Caroline S.. (2010) New loci associated with kidney function and chronic kidney disease. Nature genetics, Vol. 42, H. 5. S. 376-384.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5842964

Downloads: Statistics Overview

Abstract

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea > 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P > 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Nature Publ.
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:24 May 2013 09:22
Deposited On:24 May 2013 09:10

Repository Staff Only: item control page